Project code PN-III-P1-1.1-TE-2016-1210


Contract number 58



Radu Lefter, Alin Ciobica, Samson Guenne, Moussa Compaore, Martin Kiendrebeogo, Carol Stanciu, Anca Trifan. A Complex Behavioral Characterisation of a Rat Model of Irritable Bowel Syndrome generated by Chronic Stress Contention , Neurophysiology, 2018, Vol. 50, No. 4, (published online in November 2018), 266-277

Alin Ciobica. Biochemical and behavioral changes in rat models of irritable bowel syndrome, Acta Endocrinologica, Vol XIV, Supplement 2, October 2018

Roxana Cojocariu, Alin Ciobica, Ioana-Miruna Balmus, Samson GUENNE, Anca Trifan, Carol Stanciu, Luminita Hritcu, Radu Lefter, Antioxidant Capacity and Behavioral Relevance of a Polyphenolic Extract of Chrysanthellum americanum in a Rat Model of Irritable Bowel Syndrome, Oxidative Medicine and Cellular Longevity, 2019, Article ID 3492767, IF 4.86.

Raluca Gavril, Luminita Hritcu, Padurariu Manuela, Ciobica Alin, Cristina Horhogea, Gabriela Stefanescu, Mihaela Claudia Spataru, Crina Straulea, Cristinel Stefanescu. Preliminary study on the correlations between oxytocin levels and irritable bowel syndrome in patients with depression. REV.CHIM.(Bucharest), 70, No. 6, 2019, 2204- 2206.

Balmus Ioana – Miruna, Robea Madalina, Ciobica Alin, Daniel Timofte, Perceived stress and gastrointestinal habits in college students, Acta Endocrinologica, 2019 15: 274-275 doi: 10.4183/aeb.2019.274.

Luminita Diana Hritcu, Padurariu Manuela, Ciobica Alin, Cristina Horhogea, Mihaela Claudia Spataru, Constantin Spataru, Liviu Burtan, Cristinel Stefanescu, Serum cortisol levels modifications in patients with depression and irritable bowel syndrome REV.CHIM.(Bucharest), 70, No. 9, 2019, 3383-3386.

ROBEA MA, SĂVUCĂ A, STRUNGARU ŞA, LENZI C, GRASSO C, PLĂVAN G, CIOBICĂ A, NICOARĂ M. The general biological relevance of the oxidative stress status in replicating some neuropsychiatric and digestive–related manifestations in zebrafish. Rom Biotechnol Lett. 2019; 24(4): 571-579. DOI: 10.25083/rbl/24.4/571.579.

Yousra Massaoudi, Alin Ciobica, Irina Dobrin, Mohammed El Hassouni, Halophilic bacteria - a potential therapeutical approach for autism?, Romanian Biotechnological Letters, Rom Biotechnol Lett. 2019; 24(5): 826-836.

Balmus, I.-M.; Lefter, R.; Ciobica, A.; Cojocaru, S.; Guenne, S.; Timofte, D.; Stanciu, C.; Trifan, A.; Hritcu, L. Preliminary Biochemical Description of Brain Oxidative Stress Status in Irritable Bowel Syndrome Contention-Stress Rat Model. Medicina 2019, 55 (12), 776. doi:10.3390/medicina55120776. IF 1.467.

Balmus, IM, Ciobica, A, Cojocariu, R; Gorgan, L, Stanciu, C, Trifan, A, Correlative Studies on the Biorelevance of Smoking in Gastrointestinal Irritable Bowel Syndrome-like Symptoms, 2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB), Book Group Author(s):IEEE, Book Series: E-Health and Bioengineering Conference, Published in 2020, WOS:000558648300166, ISBN:978-1-7281-2603-6.

Balmus, IM, Ciobica, A, Cojocariu, R; Gorgan, L, Stanciu, C, Trifan, A, The Possible Biorelevance of Alcohol Consumption in some Gastrointestinal IBS-Like Symptoms - Correlative Studies Based on Surveying, 2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB), Book Group Author(s):IEEE, Book Series: E-Health and Bioengineering Conference, Published in 2020, WOS: 000558648300046, ISBN:978-1-7281-2603-6.

Cojocariu, R, Ciobica, A, Balmus, IM, Gorgan, L, Padurariu, M, Stanciu, C, Trifan, A, Some Mechanistical and Computational Aspects on the Correlations that Might Exist between Irritable Bowel Syndrome Versus Sleep Patterns and Disturbances, 2019 E-HEALTH AND BIOENGINEERING CONFERENCE (EHB), Book Group Author(s):IEEE, Book Series: E-Health and Bioengineering Conference, Published in 2020, WOS: 000558648300109, ISBN:978-1-7281-2603-6.

Radu Lefter, Alin Ciobica, Daniel Timofte, Carol Stanciu , Anca Trifan, A Descriptive Review on the Prevalence of Gastrointestinal Disturbances and their Multiple Associations in Autism Spectrum Disorder, Medicina 2020, 56(1), 11;

Ovidiu Ilie-Dumitru, Alin Ciobica, Jack McKenna, Bogdan Doroftei , Ioannis Mavroudis, Mini-review on the relations between gut microflora and Parkinson’s disease – further biochemical (oxidative stress), inflammatory and neurological particularities, Oxidative Medicine and Cellular Longevity, Volume 2020, Article ID 4518023,, 2020. IF 4.86

Ioana-Miruna Balmus, Ovidiu Ilie-Dumitru, Alin Ciobica, Roxana-Oana Cojocariu, Carol Stanciu, Anca Trifan, Mirela Cimpeanu, Cristian Cimpeanu, Lucian Gorgan, Irritable Bowel Syndrome between Molecular Approach and Clinical Expertise—Searching for Gap Fillers in the Oxidative Stress Way of Thinking Medicina 2020, 56(1), 38; IF 1,46.

Luminita Hritcu, Ilie Ovidiu Dumitru, Manuela Padurariu, Alin Ciobica, Mihaela Claudia Spataru, Constantin Spataru, Gabriela Stefanescu, Cristinel Stefanescu, Cristian Grecu-Gabos, The Modulation of Oxytocin and Cortisol Levels in Major Depression Disorder and Irritable Bowel Syndrome, Rev.Chim.(Bucharest) ,71 , no. 1 , 2020, 150-155.

Balmus Ioana-Miruna, Ciobica Alin, Cojocariu Roxana, Alina Costina Luca, Gorgan Lucian, Irritable Bowel Syndrome and the Neurological Deficiencies: Is There A Relationship? The Possible Relevance of the Oxidative Stress Status, Medicina 2020, 56(4), 175;

RADU LEFTER, ALIN CIOBICA, DANIEL TIMOFTE, DANIELA ABABEI, ROMEO DOBRIN, ANDREI LUCA, ANCA TRIFAN, CAROL STANCIU, CATALIN SFARTI, A new biological approach in generating an irritable bowel syndrome rat model -focusing on depression in sucrose splash test and body weight change, Romanian Biotechnological Letters, 2020, Vol. 25, Nr. 3, 1554-1562, DOI: 10.26327/RBL2018.208.

Ioana – Miruna Balmus, Cojocariu Roxana – Oana, Alin Ciobica, Stefan Strungaru, Roxana Strungaru – Jijie, Alina Cantemir, Catalina Galatanu, Lucian Gorgan, Preliminary Study on the Tears Oxidative Stress Status and Sleep Disturbances in Irritable Bowel Syndrome Patients, Oxidative Medicine and Cellular Longevity, vol. 2020, Article ID 4690713, 2020, IF 4.86.

Roxana Cojocariu, Ioana Miruna Balmus, Radu Lefter, Luminita Hritcu, Dana Ababei, Alin Ciobica, Simona Copaci, Lucian Copolovici, Dana Copolovici, Ștefana Jurcoane, Beneficial effects of Camelina sativa oil on behavioural (memory, anxiety, depression and social-related) manifestations and oxidative stress parameters in a mice model of irritable bowel syndrome, Romanian Biotechnological Letters, 2020, Vol. 25, Nr. 3, 1532-1540.

Alin Ciobica, Padurariu Manuela, Alexandrina Curpan, Iulia Antioch, Roxana Chirita, Cristinel Stefanescu, Alina-Costina Luca and Mihoko Tomida, Mini-review on the connections between the neuropsychiatric and dental disorders: current perspectives and the possible relevance of oxidative stress and other factors, Oxidative Medicine and Cellular Longevity, Volume 2020, Article ID 6702314,, 2020. IF 5.

Radu Lefter, Alin Ciobica, Iulia Antioch, Daniela Ababei, Luminita Hritcu, Alina-Costina Luca, Oxytocin differentiated effects according to the administration route in a prenatal valproic acid-induced rat model of autism, Medicina 2020, 56(6), 267; IF 1,46.

Antioch Iulia, Tsumugu Furuta, Ryutaro Uchikawa, Masayo Okumura, Junichi Otogoto, Eiji Kondo, Norio Sogawa, Alin Ciobica, Mihoko Tomida, The favorite music controls the pain-related response of the anterior cingulate cortex and the pain threshold on the skin, Journal of Pain Research, 2020:13 2729–2737. IF 2.386.

Gabriela Simionescu, Ovidiu-Dumitru Ilie, Alin Ciobica, Bogdan Doroftei, Radu Maftei, Delia Grab, Jack McKenna, Nitasha Dhunna, Ioannis Mavroudis, Emil Anton, Mini-review on The Possible Interconnections between The Gut-brain Axis and The Infertility-Related Neuropsychiatric Comorbidities, Brain Sciences, 2020, 10, 384; doi:10.3390/brainsci10060384, IF 2,786.

Bogdan Doroftei, Ovidiu-Dumitru Ilie, Roxana-Oana Cojocariu, Alin Ciobica, Radu Maftei, Delia Grab, Emil Anton; Jack McKenna, Nitasha Dhunna; Gabriela Simionescu, Mini-review regarding the biological cycle of the vitamin B3: focusing on the molecular interface in relation to oxidative stress, gut-brain axis functionality, and fertilization rate – possible relevance for the novel coronavirus?, Molecules, 2020, 25(15), 3323;, IF 3.267

Antioch Iulia, Ovidiu-Dumitru Ilie, Alin Ciobica, Bogdan Doroftei, Michele Fornaro. Preclinical Considerations about Affective Disorders and Pain: A Broadly Intertwined, yet Often Under-Explored, Relationship Having Major Clinical Implications . Medicina 2020, 56(10), 504; 32-1540.

Anton, C.; Ciobica, A.; Doroftei, B.; Maftei, R.; Ilea, C.; Darii Plopa, N.; Bolota, M.; Anton, E. Review of the Complex Relationship between Irritable Bowel Syndrome and Infertility Medicina 2020, 56, 592.

Roxana Oana Cojocariu, Ioana Miruna Balmus, Radu Lefter, Daniela Carmen Ababei, Alin Ciobica, Luminita Hritcu, Fatimazahra Kamal, Bogdan Doroftei, and oxidative stress changes in mice subjected to combinations of multiple stressors relevant for irritable bowel syndrome , Brain Sciences, 2020, 10(11), 865;, IF 3,33.

Ovidiu-Dumitru Ilie, Alin Ciobica, Sorin Riga, Nitasha Dhunna, Jack McKenna, Ioannis Mavroudis, Bogdan Doroftei, Adela-Magdalena Ciobanu, Dan Riga, on lipofuscin and aging: focusing on the molecular interface, the biological recycling mechanism, oxidative stress, and the gut-brain axis functionality , Medicina 2020.