Project code PN-III-P1-1.1-TE-2016-1210

Project Abstract

Contract number 58


Based on the previous experience of the PI in the relevance of the oxidative stress status in most of the neuropsychiatric disorders [ 6 papers in the "red area" - top 25% ISI (5 as main author) and 2 in the yellow area (both as main author) and Hirsch factor 19 ], we are proposing here a complex approach for understanding the relevance of oxidative stress status, inflammatory processes and neurological-related manifestations in Irritable bowel syndrome (IBS), in both animal models and human patients, as well as the interactions between these 3 factors in the aforementioned pathology.

This is justified by the increased interest in this very modern and prevalent pathology (IBS affects around 11% of the population globally), as well as the increased economical and psychological burden generated by IBS. This will be done by using the experience of a young team formed by 4 research group members in Behavioral Neuropsychopharmacology and Biochemistry, one Psychiatrist, as well as 2 researchers specialized in Gastroenterology.

Since not a single biomarker has been found for this disorder we will focus our efforts in understanding how relevant are the main oxidative/nitrosative stress and inflammation in this context, as well as their interactions with some neuro-psychiatric manifestations of this disease, especially considering that it was previously showed that depression or anxiety could exhibit strong gastrointestinal manifestations, while neuropsychiatric disorders such as schizophrenia or autism are usually including also IBS-like features in their symptomatology. Other aspects we will insist on will be to better understand the gastrointestinal nervous system modulation/enteric nerve system impairment in IBS, analyzing and developing new models of IBS in rats and understanding how the oxidative/nitrosative stress and inflammatory markers are influencing the various subtypes of IBS, its gender-related differences, as well as its genetic substrates alterations.